Current Research

The following is a collection of research studies that are in progress or planned pertaining to the application of electromagnetic stimulation for the relief of Parkinson's disease symptoms.

1. Accelerated TMS for Parkinson's Disease With Depression
   Sponsored by: Department of Veterans Affairs

   The goal of the study is to investigate a new approach to administering repetitive transcranial magnetic stimulation (rTMS) in patients with refractory depression and limited mobility due to Parkinson’s disease (PD).

   The purpose is to determinate if accelerated rTMS treatment over 1.5 days is effective for ameliorating depression in Parkinson’s disease.

   Subject profile: Males and females aged 40 - 75 years with a diagnosis Parkinson’s Disease, and who meet DSM-IV criteria for Major Depressive Episode, severe, with or without psychotic features; or for Mood Disorder Secondary to Parkinson’s Disease with major depression-like episode.

   Rationale for Study: This inpatient study will provide an initial test for the hypothesis that accelerated rTMS is an effective treatment for depression in PD. Preliminary data will also be collected on the hypothesis that accelerated rTMS will also have beneficial effects on the motor signs of PD. Follow up testing will help delineate the time course of response.

   The rTMS treatment site over left dorsolateral prefrontal cortex will be 5.5cm anterior to the hand motor area. Treatments consisting of 1000 total pulses at 10 Hz and 100% motor threshold will be administered hourly for 1.5 days, totaling 15 sessions. A comprehensive test battery will be administered just before and after treatment, at 3 weeks, and at 6 weeks after treatment.

   It is expected that accelerated rTMS treatments will lessen the degree of depression and alleviate motor symptoms of PD to the same extent as rTMS treatments of longer duration, but far more rapidly.

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Other Forms of Deep Brain Stimulation

Physicians located in Colorado, Michigan, and Florida, who have patients living with Parkinson’s disease, should know that Pico-Tesla Magnetic Therapies are currently conducting clinical trials in those three states. These trails will be used to test the efficacy of the Resonator® device which is used for pulsed magnetic therapy in treating Parkinson’s patients. This is a paid clinical trial for all patients who qualify for and complete the procedure.

All locations where these clinical trials are being held are in close proximity to major cities in each state. Any interested party can contact Pico-Tesla for more information.