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Theory of Mechanism of Operation (Continued) Empirical study over many years has yielded information about field frequencies and amplitudes affecting different tissues across various ‘windows’ of activity. Locating the precise settings applicable to a specific problem ideally requires moving across any given window to determine the optimal settings, however, field effects on a given problem or tissue disturbance can be observed when manipulated across the window. A critical issue is that of choosing the target molecule upon which the applied field strength and frequency is determined. Based on calculations derived from the Jacobson Resonance equation, it can be seen that it is the molecular weight of the target molecule that is the critical variable in the equation. We have had significant success with application of these techniques in the treatment of Parkinson’s disease. The family of Nerve Growth Factors (brain derived neurotrophic factor, neurturin, glial derived neurotrophic factor) were chosen as the target molecules for the derived fields and frequencies in the treatment of Parkinson’s Disease. These compounds have been extensively studied, with observations suggesting a wide variety of effects in the nervous system including both potentiation and depression of neuronal activity, promotion of synaptic plasticity, regulation of neuronal excitability, and promotion either of neuronal survival or apoptosis. While we cannot at this time state with certainty that Jacobson Resonance does in fact specifically affect these active target molecules, further work with in vivo magnetic resonance spectroscopy may assist in determining if this is indeed the case. On the path to collection of those data, we do have empirical evidence supporting the effects of the technique on neuronal function. One such study demonstrated statistically significant improvements in mouse forelimb grip strength after toxin induced motor neuropathy in animals treated in the Resonator. Electron microscopy of these neurons post treatment revealed enhancements in axonal regeneration as well as increased organization in mitochondrial and microtubular structure. Additional studies have shown that the Resonator significantly modulates responsiveness in autonomic nerves in the heart and was able to affect atrial fibrillation utilizing a canine model. At the present time, we do not have a hypothesis to explain the observed effects of Jacobson Resonance in patients suffering with Parkinson’s disease. In addition to the device being designated as non invasive and non significant risk, we anticipate application of the intervention in an adjunctive manner to “standard of care” approaches now utilized by physicians in the treatment of Alzheimer’s. |
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